A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Integration is vital to retroviral replication and influences the establishment of the latent HIV reservoir. HIV-1 integration favors active genes, which is in part determined by the interaction between integrase and lens epithelium-derived growth factor (LEDGF)/p75. Because gene targeting remains s...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sowd, Gregory A., Serrao, Erik, Wang, Hao, Wang, Weifeng, Fadel, Hind J., Poeschla, Eric M., Engelman, Alan N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776470/
https://ncbi.nlm.nih.gov/pubmed/26858452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524213113
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