Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma

The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a poor prognosis and is of unknown pathogenesis. We performed exome sequencing of matched normal-carcinomatous-sarcomatoid specimens from 21 subjects. Two tumors had hypermutation consistent with mismatch repair...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Bi, Mark, Zhao, Siming, Said, Jonathan W., Merino, Maria J., Adeniran, Adebowale J., Xie, Zuoquan, Nawaf, Cayce B., Choi, Jaehyuk, Belldegrun, Arie S., Pantuck, Allan J., Kluger, Harriet M., Bilgüvar, Kaya, Lifton, Richard P., Shuch, Brian
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776463/
https://ncbi.nlm.nih.gov/pubmed/26864202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525735113
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