Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma

The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a poor prognosis and is of unknown pathogenesis. We performed exome sequencing of matched normal-carcinomatous-sarcomatoid specimens from 21 subjects. Two tumors had hypermutation consistent with mismatch repair...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bi, Mark, Zhao, Siming, Said, Jonathan W., Merino, Maria J., Adeniran, Adebowale J., Xie, Zuoquan, Nawaf, Cayce B., Choi, Jaehyuk, Belldegrun, Arie S., Pantuck, Allan J., Kluger, Harriet M., Bilgüvar, Kaya, Lifton, Richard P., Shuch, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776463/
https://ncbi.nlm.nih.gov/pubmed/26864202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525735113
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