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HOT mutation screening in human glioblastomas
AIMS: Somatic mutations in IDH1 and IDH2 are described in glioblastomas (GBMs). Mutant IDH1 and IDH2 reduce α-KG to D-2HG which accumulates, and is proposed to promote tumorigenesis. HOT catalyzes the conversion of γ-hydroxybutyrate to succinic semialdehyde in a reaction that produces D-2HG. Since i...
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| Publicado en: | Future Sci OA |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Future Science Ltd
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776344/ https://ncbi.nlm.nih.gov/pubmed/26948489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fso.15.20 |
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