Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail

The chromodomain of HP1α binds directly to lysine 9-methylated histone H3 (H3K9me). This interaction is enhanced by phosphorylation of serine residues in the N-terminal tail of HP1α by unknown mechanism. Here we show that phosphorylation modulates flexibility of HP1α’s N-terminal tail, which strengt...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Shimojo, Hideaki, Kawaguchi, Ayumi, Oda, Takashi, Hashiguchi, Nobuto, Omori, Satoshi, Moritsugu, Kei, Kidera, Akinori, Hiragami-Hamada, Kyoko, Nakayama, Jun-ichi, Sato, Mamoru, Nishimura, Yoshifumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776139/
https://ncbi.nlm.nih.gov/pubmed/26934956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22527
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