Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation

Ionotropic glutamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excitatory transmission. Glutamate binding to clamshell-shaped ligand binding domains (LBDs) triggers opening of the integral ion channel, but how the four LBDs orchestrate receptor activati...

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Bibliographic Details
Published in:Biophys J
Main Authors: Baranovic, Jelena, Chebli, Miriam, Salazar, Hector, Carbone, Anna L., Faelber, Katja, Lau, Albert Y., Daumke, Oliver, Plested, Andrew J.R.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2016
Subjects:
Channels and Transporters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776031/
https://ncbi.nlm.nih.gov/pubmed/26910426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.033
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