Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages

Broad-spectrum histone deacetylase inhibitors (HDACi) are used clinically as anticancer agents, and more isoform-selective HDACi have been sought to modulate other conditions, including chronic inflammatory diseases. Mouse studies suggest that HDACi downregulate immune responses and may compromise h...

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Publicado en:Antimicrob Agents Chemother
Main Authors: Ariffin, Juliana K., das Gupta, Kaustav, Kapetanovic, Ronan, Iyer, Abishek, Reid, Robert C., Fairlie, David P., Sweet, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775968/
https://ncbi.nlm.nih.gov/pubmed/26711769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01876-15
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