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Fluconazole Susceptibility in Cryptococcus gattii Is Dependent on the ABC Transporter Pdr11

Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biol...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Yang, Mai Lee, Uhrig, John, Vu, Kiem, Singapuri, Anil, Dennis, Michael, Gelli, Angie, Thompson, George R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775963/
https://ncbi.nlm.nih.gov/pubmed/26643330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01777-15
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