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Fluconazole Susceptibility in Cryptococcus gattii Is Dependent on the ABC Transporter Pdr11

Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biol...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Yang, Mai Lee, Uhrig, John, Vu, Kiem, Singapuri, Anil, Dennis, Michael, Gelli, Angie, Thompson, George R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775963/
https://ncbi.nlm.nih.gov/pubmed/26643330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01777-15
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