Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) Based Macrocyclic Chelator for (89)Zr(4+) and Its Use for ImmunoPET Imaging of HER2 Positive Model of Ovarian Carcinoma in Mice

A novel octadentate 3-hydroxypyridin-2-one (2,3-HOPO) based di-macrocyclic ligand was evaluated for chelation of (89)Zr; subsequently, it was used as a bi-functional chelator for preparation of (89)Zr-labeled antibodies. Quantitative chelation of (89)Zr(4+) with the octadentate ligand forming (89)Zr...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: N.Tinianow, Jeff, Pandya, Darpan N., Pailloux, Sylvie L., Ogasawara, Annie, Vanderbilt, Alexander N., Gill, Herman S., Williams, Simon-P., Wadas, Thaddeus J., Magda, Darren, Marik, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Short Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775861/
https://ncbi.nlm.nih.gov/pubmed/26941844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.14261
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