Ophiopogonin D maintains Ca(2+) homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress

AIM: CYP2J3 in myocardium metabolizes arachidonic acid to 4 regioisomeric epoxyeicosatrienoic acids (EETs), which have diverse biological activities in rat heart. In this study we examined whether CYP2J3 was involved in cardioprotective effects of ophiopogonin D (OPD), a steroidal glycoside isolated...

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Publicat a:Acta Pharmacol Sin
Autors principals: You, Wen-ting, Zhou, Tao, Ma, Zeng-chun, Liang, Qian-de, Xiao, Cheng-rong, Tang, Xiang-lin, Tan, Hong-ling, Zhang, Bo-li, Wang, Yu-guang, Gao, Yue
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775850/
https://ncbi.nlm.nih.gov/pubmed/26838069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.146
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