A Prognostic Gene Expression Signature in the Molecular Classification of Chemotherapy-naïve Urothelial Cancer is Predictive of Clinical Outcomes from Neoadjuvant Chemotherapy: A Phase 2 Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin with Bevacizumab in Urothelial Cancer

BACKGROUND: Gene expression profiling (GEP) suggests there are three subtypes of muscle-invasive urothelial cancer (UC): basal, which has the worst prognosis; p53-like; and luminal. We hypothesized that GEP of transurethral resection (TUR) and cystectomy specimens would predict subtypes that could b...

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Detalhes bibliográficos
Publicado no:Eur Urol
Main Authors: McConkey, David J., Choi, Woonyoung, Shen, Yu, Lee, I.-Ling, Porten, Sima, Matin, Surena F., Kamat, Ashish M., Corn, Paul, Millikan, Randall E., Dinney, Colin, Czerniak, Bogdan, Siefker-Radtke, Arlene O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775435/
https://ncbi.nlm.nih.gov/pubmed/26343003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2015.08.034
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