Identification of the cell-intrinsic and extrinsic pathways downstream of EGFR and IFNγ that induce PD-L1 expression in head and neck cancer

Many cancer types, including head and neck cancers (HNC), express programmed death ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1), inhibits the function of activated T cells and results in an immunosuppressive microenvironment, but the stimuli that induce PD-...

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Publicado no:Cancer Res
Main Authors: Concha-Benavente, Fernando, Srivastava, Raghvendra M., Trivedi, Sumita, Lei, Yu, Chandran, Uma, Seethala, Raja R., Freeman, Gordon J., Ferris, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775348/
https://ncbi.nlm.nih.gov/pubmed/26676749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2001
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