Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis

PURPOSE: We demonstrated that Amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) is a tumor growth suppressor and prognostic marker in human bladder cancer. Here we determine how AGL loss enhances tumor growth, hoping to find therapeutically tractable targets/pathways that could be used in...

Full description

Saved in:
Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Guin, Sunny, Ru, Yuanbin, Agarwal, Neeraj, Lew, Carolyn R., Owens, Charles, Comi, Giacomo P., Theodorescu, Dan
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775343/
https://ncbi.nlm.nih.gov/pubmed/26490312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1706
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items