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UGT genotyping in belinostat dosing
Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1 substrates, of which irinotecan is a widely-descri...
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| Publicado en: | Pharmacol Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4775324/ https://ncbi.nlm.nih.gov/pubmed/26773202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.01.002 |
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