Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Neuroblastoma is a pediatric malignancy that typically arises in early childhood and is derived from the developing sympathetic nervous system. Clinical phenotypes range from localized tumors with excellent outcomes to widely metastatic disease where long-term survival is approximately 40% despite i...

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Publicado no:Nature
Main Authors: Oldridge, Derek A., Wood, Andrew C., Weichert-Leahey, Nina, Crimmins, Ian, Sussman, Robyn, Winter, Cynthia, McDaniel, Lee D., Diamond, Maura, Hart, Lori S., Zhu, Shizhen, Durbin, Adam D., Abraham, Brian J., Anders, Lars, Tian, Lifeng, Zhang, Shile, Wei, Jun S., Khan, Javed, Bramlett, Kelli, Rahman, Nazneen, Capasso, Mario, Iolascon, Achille, Gerhard, Daniela S., Guidry Auvil, Jaime M., Young, Richard A., Hakonarson, Hakon, Diskin, Sharon J., Look, A. Thomas, Maris, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775078/
https://ncbi.nlm.nih.gov/pubmed/26560027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15540
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