Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

BACKGROUND: As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) is found in high levels in ALL cells. Nevertheless, the ALL lymphocyte proliferation rate for the average patient is surp...

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Veröffentlicht in:BMC Syst Biol
Hauptverfasser: Ouzounoglou, Eleftherios, Dionysiou, Dimitra, Stamatakos, Georgios S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774111/
https://ncbi.nlm.nih.gov/pubmed/26932523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-016-0264-5
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