DEREGULATION OF DUX4 AND ERG IN ACUTE LYMPHOBLASTIC LEUKEMIA

Chromosomal rearrangements deregulating hematopoietic transcription factors are common in acute lymphoblastic leukemia (ALL).(1,2) Here, we show that deregulation of the homeobox transcription factor gene DUX4 and the ETS transcription factor gene ERG are hallmarks of a subtype of B-progenitor ALL t...

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Publicat a:Nat Genet
Autors principals: Zhang, Jinghui, McCastlain, Kelly, Yoshihara, Hiroki, Xu, Beisi, Chang, Yunchao, Churchman, Michelle L., Wu, Gang, Li, Yongjin, Wei, Lei, Iacobucci, Ilaria, Liu, Yu, Qu, Chunxu, Wen, Ji, Edmonson, Michael, Payne-Turner, Debbie, Kaufmann, Kerstin B., Takayanagi, Shin-ichiro, Wienholds, Erno, Waanders, Esmé, Ntziachristos, Panagiotis, Bakogianni, Sofia, Wang, Jingjing, Aifantis, Iannis, Roberts, Kathryn G., Ma, Jing, Song, Guangchun, Easton, John, Mulder, Heather L., Chen, Xiang, Newman, Scott, Ma, Xiaotu, Rusch, Michael, Gupta, Pankaj, Boggs, Kristy, Vadodaria, Bhavin, Dalton, James, Liu, Yanling, Valentine, Marcus L, Ding, Li, Lu, Charles, Fulton, Robert S., Fulton, Lucinda, Tabib, Yashodhan, Ochoa, Kerri, Devidas, Meenakshi, Pei, Deqing, Cheng, Cheng, Yang, Jun, Evans, William E., Relling, Mary V., Pui, Ching-Hon, Jeha, Sima, Harvey, Richard C., Chen, I-Ming L, Willman, Cheryl L., Marcucci, Guido, Bloomfield, Clara D., Kohlschmidt, Jessica, Mrózek, Krzysztof, Paietta, Elisabeth, Tallman, Martin S., Stock, Wendy, Foster, Matthew C., Racevskis, Janis, Rowe, Jacob M., Luger, Selina, Kornblau, Steven M., Shurtleff, Sheila A, Raimondi, Susana C., Mardis, Elaine R., Wilson, Richard K., Dick, John E., Hunger, Stephen P, Loh, Mignon L., Downing, James R., Mullighan, Charles G.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144107/
https://ncbi.nlm.nih.gov/pubmed/27776115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3691
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