Sequential monitoring and stability of ex vivo-expanded autologous and non-autologous regulatory T cells following infusion in non-human primates

Ex vivo-expanded cynomolgus monkey CD4(+)CD25(+)CD127(−) regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation through 3 rounds of expansion. When CFSE- or VPD450-labeled autologous (auto) and no...

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Détails bibliographiques
Publié dans:Am J Transplant
Auteurs principaux: Zhang, H., Guo, H., Lu, L., Zahorchak, A. F., Wiseman, R. W., Raimondi, G., Cooper, D. K. C., Ezzelarab, M. B., Thomson, A. W.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773915/
https://ncbi.nlm.nih.gov/pubmed/25783759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.13113
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