Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention

Metapristone is the most predominant biological active metabolite of mifepristone, and being developed as a novel cancer metastasis chemopreventive agent by us. Despite its prominent metastasis chemopreventive effect, the underlying mechanism remains elusive. Our study, for the first time, demonstra...

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Udgivet i:Sci Rep
Main Authors: Yu, Suhong, Yan, Cuicui, Yang, Xingtian, He, Sudang, Liu, Jian, Qin, Chongtao, Huang, Chuanzhong, Lu, Yusheng, Tian, Zhongping, Jia, Lee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773818/
https://ncbi.nlm.nih.gov/pubmed/26932781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22388
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