Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Oxidative stress is a very frequent source of DNA damage. Many cellular DNA polymerases (Pols) can incorporate ribonucleotides (rNMPs) during DNA synthesis. However, whether oxidative stress-triggered DNA repair synthesis contributes to genomic rNMPs incorporation is so far not fully understood. Hum...

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Vydáno v:Nat Commun
Hlavní autoři: Crespan, Emmanuele, Furrer, Antonia, Rösinger, Marcel, Bertoletti, Federica, Mentegari, Elisa, Chiapparini, Giulia, Imhof, Ralph, Ziegler, Nathalie, Sturla, Shana J., Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773436/
https://ncbi.nlm.nih.gov/pubmed/26917111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10805
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