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The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
The spindle checkpoint senses unattached kinetochores and inhibits the Cdc20-bound anaphase-promoting complex or cyclosome (APC/C), to delay anaphase, thereby preventing aneuploidy. A critical checkpoint inhibitor of APC/C(Cdc20) is the mitotic checkpoint complex (MCC). It is unclear whether MCC suf...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4773433/ https://ncbi.nlm.nih.gov/pubmed/26912231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10818 |
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