RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

Recent high-throughput studies revealed recurrent RUNX1 mutations in breast cancer, specifically in oestrogen receptor-positive (ER(+)) tumours. However, mechanisms underlying the implied RUNX1-mediated tumour suppression remain elusive. Here, by depleting mammary epithelial cells of RUNX1 in vivo a...

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Pubblicato in:Nat Commun
Autori principali: Chimge, Nyam-Osor, Little, Gillian H., Baniwal, Sanjeev K., Adisetiyo, Helty, Xie, Ying, Zhang, Tian, O'Laughlin, Andie, Liu, Zhi Y., Ulrich, Peaches, Martin, Anthony, Mhawech-Fauceglia, Paulette, Ellis, Matthew J., Tripathy, Debu, Groshen, Susan, Liang, Chengyu, Li, Zhe, Schones, Dustin E., Frenkel, Baruch
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773428/
https://ncbi.nlm.nih.gov/pubmed/26916619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10751
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