The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope

OBJECTIVES: This study was designed to identify common HIV-1 mutation complexes affecting the slope of inhibition curve, and to propose a new parameter incorporating both the IC50 and the slope to evaluate phenotypic resistance. METHODS: Utilizing site-directed mutagenesis, we constructed 22 HIV-1 c...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Chang, Shuai, Zhuang, Daomin, Guo, Wei, Li, Lin, Zhang, Wenfu, Liu, Siyang, Li, Hanping, Liu, Yongjian, Bao, Zuoyi, Han, Jingwan, Song, Hongbin, Li, Jingyun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773073/
https://ncbi.nlm.nih.gov/pubmed/26930645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149467
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items