The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope

OBJECTIVES: This study was designed to identify common HIV-1 mutation complexes affecting the slope of inhibition curve, and to propose a new parameter incorporating both the IC50 and the slope to evaluate phenotypic resistance. METHODS: Utilizing site-directed mutagenesis, we constructed 22 HIV-1 c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chang, Shuai, Zhuang, Daomin, Guo, Wei, Li, Lin, Zhang, Wenfu, Liu, Siyang, Li, Hanping, Liu, Yongjian, Bao, Zuoyi, Han, Jingwan, Song, Hongbin, Li, Jingyun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773073/
https://ncbi.nlm.nih.gov/pubmed/26930645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149467
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