Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP

Objective. To clarify the impact of H221Y mutation on drug resistance to NVP. Methods. 646 bp HIV-1 pol gene fragments (from 592 to 1237 nucleotide) with different NNRTIs mutation profiles from AIDS patients receiving antiretroviral therapy containing NVP regimens were introduced into pNL4-3 backbon...

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Main Authors: Jiao, Liyan, Li, Hanping, Li, Lin, Zhuang, Daomin, Liu, Yongjian, Bao, Zuoyi, Liu, Siyang, Li, Jingyun
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318213/
https://ncbi.nlm.nih.gov/pubmed/22536497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/637263
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