Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia

BACKGROUND: Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug selection pressure from the antimalarial sulfadoxin...

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Publicat a:PLoS One
Autors principals: Grigg, Matthew J., Barber, Bridget E., Marfurt, Jutta, Imwong, Mallika, William, Timothy, Bird, Elspeth, Piera, Kim A., Aziz, Ammar, Boonyuen, Usa, Drakeley, Christopher J., Cox, Jonathan, White, Nicholas J., Cheng, Qin, Yeo, Tsin W., Auburn, Sarah, Anstey, Nicholas M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773021/
https://ncbi.nlm.nih.gov/pubmed/26930493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149519
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