Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia

BACKGROUND: Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug selection pressure from the antimalarial sulfadoxin...

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Pubblicato in:PLoS One
Autori principali: Grigg, Matthew J., Barber, Bridget E., Marfurt, Jutta, Imwong, Mallika, William, Timothy, Bird, Elspeth, Piera, Kim A., Aziz, Ammar, Boonyuen, Usa, Drakeley, Christopher J., Cox, Jonathan, White, Nicholas J., Cheng, Qin, Yeo, Tsin W., Auburn, Sarah, Anstey, Nicholas M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773021/
https://ncbi.nlm.nih.gov/pubmed/26930493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149519
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