Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

Old age is associated with a progressive decline of mitochondrial function and changes in nuclear chromatin. However, little is known about how metabolic activity and epigenetic modifications change as organisms reach their midlife. Here, we assessed how cellular metabolism and protein acetylation c...

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Vydáno v:EMBO Rep
Hlavní autoři: Peleg, Shahaf, Feller, Christian, Forne, Ignasi, Schiller, Evelyn, Sévin, Daniel C, Schauer, Tamas, Regnard, Catherine, Straub, Tobias, Prestel, Matthias, Klima, Caroline, Schmitt Nogueira, Melanie, Becker, Lore, Klopstock, Thomas, Sauer, Uwe, Becker, Peter B, Imhof, Axel, Ladurner, Andreas G
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772992/
https://ncbi.nlm.nih.gov/pubmed/26781291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541132
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