Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

Transcriptional reactivation of TERT, the catalytic subunit of telomerase, is necessary for cancer progression in about 90% of human cancers. The recent discovery of two prevalent somatic mutations—C250T and C228T—in the TERT promoter in various cancers has provided insight into a plausible mechanis...

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Publicado no:Nat Cell Biol
Main Authors: Li, Yinghui, Zhou, Qi-Ling, Sun, Wenjie, Chandrasekharan, Prashant, Cheng, Hui Shan, Ying, Zhe, Lakshmanan, Manikandan, Raju, Anandhkumar, Tenen, Daniel G., Cheng, Shi-Yuan, Chuang, Kai-Hsiang, Li, Jun, Prabhakar, Shyam, Li, Mengfeng, Tergaonkar, Vinay
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772727/
https://ncbi.nlm.nih.gov/pubmed/26389665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3240
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