Direct Evidence of Target Inhibition with anti-VEGF, EGFR, and mTOR Therapies in a Clinical Model of Wound Healing

PURPOSE: In early clinical testing, most novel targeted anti-cancer therapies have limited toxicities and limited efficacy, which complicates dose and schedule selection for these agents. Confirmation of target inhibition is critical for rational drug development; however, repeated tumor biopsies ar...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Jia, Jingquan, Dellinger, Andrew E., Weiss, Eric S., Bulusu, Anuradha, Rushing, Christel, Li, Haiyan, Howard, Leigh A., Kaplan, Neal, Pang, Herbert, Hurwitz, Herbert I., Nixon, Andrew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772720/
https://ncbi.nlm.nih.gov/pubmed/25878330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2819
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