Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis

BACKGROUND: Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX, potentially constituting an initial stimulus for this conditioned response. T...

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Vydáno v:Pediatr Rheumatol Online J
Hlavní autoři: Scheuern, Andrea, Fischer, Nadine, McDonald, Joseph, Brunner, Hermine I., Haas, Johannes-Peter, Hügle, Boris
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772529/
https://ncbi.nlm.nih.gov/pubmed/26928923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12969-016-0071-y
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