A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells

The inactivation of p53 creates a major challenge for inducing apoptosis in cancer cells. An attractive strategy is to identify and subsequently target the survival signals in p53 defective cancer cells. Here we uncover a RUNX2-mediated survival signal in p53 defective cancer cells. The inhibition o...

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Foilsithe in:PLoS Genet
Main Authors: Shin, Min Hwa, He, Yunlong, Marrogi, Eryney, Piperdi, Sajida, Ren, Ling, Khanna, Chand, Gorlick, Richard, Liu, Chengyu, Huang, Jing
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771715/
https://ncbi.nlm.nih.gov/pubmed/26925584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005884
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