cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma

Bone marrow-derived mesenchymal stem cells (BMSCs) are proposed as the cells of origin of several subtypes of osteosarcoma (OS). However, signals that direct BMSCs to form different subtypes of OS are unclear. Here we show that the default tumor type from spontaneously transformed p53 knockout (p53_...

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Udgivet i:Stem Cell Reports
Main Authors: He, Yunlong, Zhu, Wentao, Shin, Min Hwa, Gary, Joy, Liu, Chengyu, Dubois, Wendy, Hoover, Shelley B., Jiang, Shunlin, Marrogi, Eryney, Mock, Beverly, Simpson, R. Mark, Huang, Jing
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470112/
https://ncbi.nlm.nih.gov/pubmed/28552607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.04.029
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