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XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
The ability to ensure proteostasis is critical for maintaining proper cell function and organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum unfolded protein response (UPR(ER)) in aging of C. elegans and found that age-onset loss of ER proteostasis could...
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| Publicado no: | Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4771415/ https://ncbi.nlm.nih.gov/pubmed/23791175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.042 |
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