Acquired EGFR C797S mediates resistance to AZD9291 in advanced non-small cell lung cancer harboring EGFR T790M

Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291. We first performed next-generation sequencing of cfDNA from seven subjects and...

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Udgivet i:Nat Med
Main Authors: Thress, Kenneth S., Paweletz, Cloud P., Felip, Enriqueta, Cho, Byoung Chul, Stetson, Daniel, Dougherty, Brian, Lai, Zhongwu, Markovets, Aleksandra, Vivancos, Ana, Kuang, Yanan, Ercan, Dalia, Matthews, Sarah, Cantarini, Mireille, Barrett, J. Carl, Jänne, Pasi A., Oxnard, Geoffrey R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771182/
https://ncbi.nlm.nih.gov/pubmed/25939061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3854
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