Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity

VTX-2337 (USAN: motolimod) is a selective toll-like receptor 8 (TLR8) agonist, which is in clinical development as an immunotherapy for multiple oncology indications, including squamous cell carcinoma of the head and neck (SCCHN). Activation of TLR8 enhances natural killer cell activation, increases...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Dietsch, Gregory N., Lu, Hailing, Yang, Yi, Morishima, Chihiro, Chow, Laura Q., Disis, Mary L., Hershberg, Robert M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771163/
https://ncbi.nlm.nih.gov/pubmed/26928328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148764
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