Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

Protein tyrosine kinases (PTKs) are a group of closely related enzymes that have evolutionarily diverged from serine/threonine kinases (STKs) to regulate pathways associated with multi-cellularity. Evolutionary divergence of PTKs from STKs has occurred through accumulation of mutations in the active...

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發表在:PLoS Genet
Main Authors: Mohanty, Smita, Oruganty, Krishnadev, Kwon, Annie, Byrne, Dominic P., Ferries, Samantha, Ruan, Zheng, Hanold, Laura E., Katiyar, Samiksha, Kennedy, Eileen J., Eyers, Patrick A., Kannan, Natarajan
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771162/
https://ncbi.nlm.nih.gov/pubmed/26925779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005885
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