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Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment

The inheritance of the ε4 allele of apolipoprotein E (ApoE4) and cholinergic system dysfunction have long been associated with the pathology of Alzheimer’s disease (AD). Recently, in vitro studies have established a direct link between ApoE and cholinergic function in that synthetic peptides contain...

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Bibliografiska uppgifter
I publikationen:Brain Res Bull
Huvudupphovsmän: Eddins, Donnie, Klein, Rebecca C., Yakel, Jerrel L., Levin, Edward D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770792/
https://ncbi.nlm.nih.gov/pubmed/19185602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2009.01.003
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