Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells

Leukemia remains life-threatening despite remarkable advances in chemotherapy. The poor prognosis and drug resistance are challenging treatment. Novel drugs are urgently needed. Shikonin, a natural naphthoquinone, has been previously shown by us to be particularly effective towards various leukemia...

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Опубликовано в: :Oncotarget
Главные авторы: Zhao, Qiaoli, Assimopoulou, Andreana N., Klauck, Sabine M., Damianakos, Harilaos, Chinou, Ioanna, Kretschmer, Nadine, Rios, José-Luis, Papageorgiou, Vassilios P., Bauer, Rudolf, Efferth, Thomas
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770748/
https://ncbi.nlm.nih.gov/pubmed/26472107
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