The Effects of Sequence Variation on Genome-wide NRF2 Binding—New Target Genes and Regulatory SNPs

Transcription factor binding specificity is crucial for proper target gene regulation. Motif discovery algorithms identify the main features of the binding patterns, but the accuracy on the lower affinity sites is often poor. Nuclear factor E2-related factor 2 (NRF2) is a ubiquitous redox-activated...

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發表在:Nucleic Acids Res
Main Authors: Kuosmanen, Suvi M., Viitala, Sari, Laitinen, Tuomo, Peräkylä, Mikael, Pölönen, Petri, Kansanen, Emilia, Leinonen, Hanna, Raju, Suresh, Wienecke-Baldacchino, Anke, Närvänen, Ale, Poso, Antti, Heinäniemi, Merja, Heikkinen, Sami, Levonen, Anna-Liisa
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
主題:
Molecular Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770247/
https://ncbi.nlm.nih.gov/pubmed/26826707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw052
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