The Effects of Sequence Variation on Genome-wide NRF2 Binding—New Target Genes and Regulatory SNPs

Transcription factor binding specificity is crucial for proper target gene regulation. Motif discovery algorithms identify the main features of the binding patterns, but the accuracy on the lower affinity sites is often poor. Nuclear factor E2-related factor 2 (NRF2) is a ubiquitous redox-activated...

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Udgivet i:Nucleic Acids Res
Main Authors: Kuosmanen, Suvi M., Viitala, Sari, Laitinen, Tuomo, Peräkylä, Mikael, Pölönen, Petri, Kansanen, Emilia, Leinonen, Hanna, Raju, Suresh, Wienecke-Baldacchino, Anke, Närvänen, Ale, Poso, Antti, Heinäniemi, Merja, Heikkinen, Sami, Levonen, Anna-Liisa
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770247/
https://ncbi.nlm.nih.gov/pubmed/26826707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw052
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