Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

During protein synthesis, ribosomes become stalled on polyproline-containing sequences, unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and in bacteria by the homologous protein EF-P. While a structure of EF-P bound to the 70S ribosome exists, structural insi...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Schmidt, Christian, Becker, Thomas, Heuer, André, Braunger, Katharina, Shanmuganathan, Vivekanandan, Pech, Markus, Berninghausen, Otto, Wilson, Daniel N., Beckmann, Roland
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770232/
https://ncbi.nlm.nih.gov/pubmed/26715760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1517
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