Structural hot spots for the solubility of globular proteins

Natural selection shapes protein solubility to physiological requirements and recombinant applications that require higher protein concentrations are often problematic. This raises the question whether the solubility of natural protein sequences can be improved. We here show an anti-correlation betw...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ganesan, Ashok, Siekierska, Aleksandra, Beerten, Jacinte, Brams, Marijke, Van Durme, Joost, De Baets, Greet, Van der Kant, Rob, Gallardo, Rodrigo, Ramakers, Meine, Langenberg, Tobias, Wilkinson, Hannah, De Smet, Frederik, Ulens, Chris, Rousseau, Frederic, Schymkowitz, Joost
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770091/
https://ncbi.nlm.nih.gov/pubmed/26905391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10816
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