Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors

BACKGROUND: α3β1 integrin is overexpressed in several types of human cancer and is associated with poor prognosis, metastasis, and resistance to cancer treatment. We previously identified a cyclic peptide ligand LXY1 that specifically binds to the α3β1 integrin on human glioblastoma U-87MG cells. He...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Xiao, Wenwu, Li, Tianhong, Bononi, Fernanda C., Lac, Diana, Kekessie, Ivy A., Liu, Yanlei, Sanchez, Eduardo, Mazloom, Anisha, Ma, Ai-hong, Lin, Jia, Tran, Jimmy, Yang, Kevin, Lam, Kit S., Liu, Ruiwu
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769701/
https://ncbi.nlm.nih.gov/pubmed/26922417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0165-z
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