Next Generation Sequencing of Cytokeratin 20-Negative Merkel Cell Carcinoma Reveals Ultraviolet Signature Mutations and Recurrent TP53 and RB1 Inactivation

Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin-20 (CK20) is expressed in approximately 95% of Merkel cell carcinomas and is useful for distinction from morphologically similar entities including metastatic small cell lung carcinoma. Lack of CK20...

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Publicado en:Mod Pathol
Main Authors: Harms, Paul W., Collie, Angela M. B., Hovelson, Daniel H., Cani, Andi K., Verhaegen, Monique E., Patel, Rajiv M., Fullen, Douglas R., Omata, Kei, Dlugosz, Andrzej A., Tomlins, Scott A., Billings, Steven D.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769666/
https://ncbi.nlm.nih.gov/pubmed/26743471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2015.154
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