Next Generation Sequencing of Cytokeratin 20-Negative Merkel Cell Carcinoma Reveals Ultraviolet Signature Mutations and Recurrent TP53 and RB1 Inactivation

Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin-20 (CK20) is expressed in approximately 95% of Merkel cell carcinomas and is useful for distinction from morphologically similar entities including metastatic small cell lung carcinoma. Lack of CK20...

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Publicat a:Mod Pathol
Autors principals: Harms, Paul W., Collie, Angela M. B., Hovelson, Daniel H., Cani, Andi K., Verhaegen, Monique E., Patel, Rajiv M., Fullen, Douglas R., Omata, Kei, Dlugosz, Andrzej A., Tomlins, Scott A., Billings, Steven D.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769666/
https://ncbi.nlm.nih.gov/pubmed/26743471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2015.154
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