Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers

Eluxadoline, an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist developed for the treatment of diarrhea-predominant irritable bowel syndrome, normalizes gastrointestinal (GI) transit and defecation under conditions of novel environment stress or post-inflammato...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Fujita, Wakako, Gomes, Ivone, Dove, Leonard S., Prohaska, David, McIntyre, Gail, Devi, Lakshmi A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769596/
https://ncbi.nlm.nih.gov/pubmed/25261794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.09.015
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