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Improvement in detection of minor alleles in next generation sequencing by base quality recalibration
BACKGROUND: Minor allele detection in very high coverage sequence data (>1000X) has many applications such as detecting mtDNA heteroplasmy, somatic mutations in cancer or tumors, SNP calling in pool sequencing, etc., where reads with low frequency are not necessarily sequence error but may instea...
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| Publicado no: | BMC Genomics |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4769523/ https://ncbi.nlm.nih.gov/pubmed/26920804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2463-2 |
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