Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

BACKGROUND: Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we inv...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Bashari, Muhammad Hasan, Fan, Fengjuan, Vallet, Sonia, Sattler, Martin, Arn, Melissa, Luckner-Minden, Claudia, Schulze-Bergkamen, Henning, Zörnig, Inka, Marme, Frederik, Schneeweiss, Andreas, Cardone, Michael H., Opferman, Joseph T., Jäger, Dirk, Podar, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769490/
https://ncbi.nlm.nih.gov/pubmed/26921175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0686-4
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