Unfolding of a temperature-sensitive domain controls voltage-gated channel activation

Voltage-gated ion channels (VGICs) are outfitted with diverse cytoplasmic domains that impact function. To examine how such elements may affect VGIC behavior, we addressed how the bacterial voltage-gated sodium channel (BacNa(V)) C-terminal cytoplasmic domain (CTD) affects function. Our studies show...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Arrigoni, Cristina, Rohaim, Ahmed, Shaya, David, Findeisen, Felix, Stein, Richard A., Nurva, Shailika Reddy, Mishra, Smriti, Mchaourab, Hassane S., Minor, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769381/
https://ncbi.nlm.nih.gov/pubmed/26919429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.001
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