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Apo-states of calmodulin and CaBP1 control Ca(V)1 voltage-gated calcium channel function through direct competition for the IQ domain
In neurons, binding of calmodulin (CaM) or calcium-binding protein 1 (CaBP1) to the Ca(V)1 (L-type) voltage-gated calcium channel IQ domain endows the channel with diametrically opposed properties. CaM causes calcium-dependent inactivation (CDI) and limits calcium entry, whereas CaBP1 blocks CDI and...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839849/ https://ncbi.nlm.nih.gov/pubmed/23811053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.06.024 |
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